Chemistry Heterocyclic Building Blocks Piperazines 2-(piperazin-1-yl)pyrazine

2-(piperazin-1-yl)pyrazine

Ambeed provide 9 derivatives of 2-(piperazin-1-yl)pyrazine.

These compounds have the same murcko framework: 2-(piperazin-1-yl)pyrazine.

Substitution Reactions: The piperazine ring can undergo substitution reactions, where a functional group or atom replaces a hydrogen atom on the ring. For example, you can perform N-alkylation or N-acylation reactions on the piperazine ring.
Amination: You can introduce additional amino groups onto the piperazine ring through amination reactions.
Oxidation: The compound can undergo oxidation reactions, converting the pyrazine ring or piperazine ring into oxidized derivatives.
Halogenation: You can halogenate the compound by replacing hydrogen atoms with halogen atoms (e.g., bromination or chlorination).
Cross-coupling Reactions: If there are suitable functional groups on the molecule, you can perform cross-coupling reactions with other organic compounds to create more complex structures.
Reduction: You can reduce functional groups in the molecule using reducing agents to convert them to their respective reduced forms.
Cyclization: The compound can participate in cyclization reactions to form ring structures, especially if there are suitable functional groups for intramolecular reactions.

Further Reading:
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Framework+−

(9H-fluoren-9-yl)methyl piperazine-1-carboxylate (R)-2-benzylpiperazine 1,4-diphenylpiperazine 1-(2-chlorophenyl)piperazine 1-(2-fluorophenyl)piperazine 1-(3-methoxyphenyl)piperazine 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine 1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine 1-(methylsulfonyl)piperazine 1-(phenylsulfonyl)piperazine 1-(piperidin-4-yl)piperazine 1-(pyridin-3-yl)piperazine 1-(pyridin-3-ylmethyl)piperazine 1-benzhydryl-4-benzylpiperazine 1-benzhydrylpiperazine 1-benzyl 4-(tert-butyl) piperazine-1,4-dicarboxylate 1-benzyl-4-methylpiperazine 1-ethyl-4-phenylpiperazine 1-ethylpiperazine 1-isopropylpiperazine 1-methyl-4-(pyridin-2-yl)piperazine 1-methyl-4-phenylpiperazine 1-methylpiperazin-2-one 1-methylpiperazine 10-(3-(piperazin-1-yl)propyl)-10H-phenothiazine 2-(4-(benzyloxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-(piperazin-1-yl)benzonitrile 2-(piperazin-1-yl)ethan-1-amine 2-(piperazin-1-yl)ethan-1-ol 2-(piperazin-1-yl)pyrazine 2-(piperazin-1-yl)pyrimidine 2-phenylpiperazine 3-(piperazin-1-yl)aniline 3-(piperazin-1-yl)benzoic acid 3-(piperazin-1-yl)pyridazine 3-methylpiperazin-2-one 4-(piperazin-1-yl)benzaldehyde 4-(piperazin-1-yl)pyrimidine benzyl 2-methylpiperazine-1-carboxylate benzyl 3-(hydroxymethyl)piperazine-1-carboxylate benzyl 3-methylpiperazine-1-carboxylate phenyl(piperazin-1-yl)methanone piperazine-2,5-dione tert-butyl 3-oxopiperazine-1-carboxylate tert-butyl 4-(pyridin-2-yl)piperazine-1-carboxylate tert-butyl 4-benzylpiperazine-1-carboxylate tert-butyl 4-phenylpiperazine-1-carboxylate tert-butyl piperazine-1-carboxylate

By Key Group+−

benzothiophene-piperazine benzylpiperazine boc-piperazine butylpiperazine cyanopiperazine dimethylpiperazine dioxaborolane-piperazine ethylpiperazine formylpiperazine hydroxyethyl-piperazine hydroxymethyl-piperazine-carboxylate indazo-piperazine isobutylpiperazine isopropylpiperazine methylpiperazine oxopiperazine phenylpiperazine piperazin-amine piperazin-pyrimidin piperazine-carboxylate piperazine-carboxylic acid piperazine-hydrochloride piperazine-hydroxyl piperazine-methanol piperazine-pyrazine piperazine-pyridine piperazine-quinoline propylpiperazine pyrazol-piperazine sulfonyl-piperazine trifluoromethyl-phenyl-piperazin trifluoromethyl-piperazine trimethylpiperazine

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Aliphatic Heterocycles Aromatic Heterocycles Azetidines Benzimidazoles Benzofurans Benzothiazoles Benzothiophenes Dioxolanes Furans Imidazoles Imidazolines Indazoles Indoles Morpholines Non-Halogenated Heterocycles Other Aromatic Heterocycles Oxetanes Phthalazines Piperidines Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Quinazolines Quinolines Spiroes Tetrahydrofurans Thiazoles Triazoles

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Alcohols Aldehydes Alkenyls Alkyls Alkynyls Amides Amines Aryls Bromides Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Hydrazides Hydrazines Ketones Nitriles Nitroes Organoboron Phenols Sulfamides Sulfones Sulfonic Acids Sulfonyl Chlorides Thioureas Trifluoromethyls Ureas

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    By Configuration+−

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