Chemistry Heterocyclic Building Blocks Pyrimidines 2-(piperidin-1-yl)pyrimidine
Ambeed provide 16 derivatives of 2-(piperidin-1-yl)pyrimidine.
These compounds have the same murcko framework: 2-(piperidin-1-yl)pyrimidine.
Acylation: You can acylate the amino group in the piperidine ring or the nitrogen atoms in the pyrimidine ring using acylating agents like acyl chlorides or anhydrides. This reaction can introduce acyl groups (RCO-) onto the molecule.
Alkylation: The piperidine nitrogen can be alkylated with alkyl halides or sulfonates to introduce alkyl groups.
Nucleophilic Substitution: The piperidine nitrogen is nucleophilic and can undergo substitution reactions with electrophiles. For example, it can react with alkyl halides to form N-alkylated products.
Ring Opening: The piperidine ring can undergo ring-opening reactions under certain conditions. For instance, it can be cleaved to form an open-chain compound.
Cross-Coupling Reactions: You can perform cross-coupling reactions with appropriate reagents to form C-C or C-N bonds. Palladium-catalyzed reactions like Suzuki-Miyaura or Buchwald-Hartwig coupling could be employed.
Reduction: You can reduce the pyrimidine ring or the piperidine ring using reducing agents like hydrogen and a catalyst or metal hydrides to form the corresponding reduced products.
Oxidation: Oxidizing agents can be used to oxidize the compound, potentially introducing functional groups such as ketones or aldehydes.
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1-(Pyrimidin-2-yl)piperidin-4-amine dihydrochloride
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Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate
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1-(4-(Trifluoromethyl)pyrimidin-2-yl)piperidin-4-ol
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1-(5-Bromopyrimidin-2-yl)-3-piperidinol
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(1-(5-Bromopyrimidin-2-yl)piperidin-3-yl)methanol
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(2-(4-(Methoxycarbonyl)piperidin-1-yl)pyrimidin-5-yl)boronic acid
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Methyl 1-(5-bromopyrimidin-2-yl)piperidine-4-carboxylate
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3-(1-(5-Ethylpyrimidin-2-yl)piperidin-4-yl)propan-1-ol
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(2-(Piperidin-1-yl)pyrimidin-5-yl)boronic acid
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Ethyl 1-(4-(trifluoromethyl)pyrimidin-2-yl)piperidine-4-carboxylate
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1-(Pyrimidin-2-yl)piperidine-4-carboxylic acid
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Ethyl 1-pyrimidin-2-yl-piperidine-4-carboxylate