Chemistry Heterocyclic Building Blocks Piperidines 2-(piperidin-4-yl)pyridine
Ambeed provide 5 derivatives of 2-(piperidin-4-yl)pyridine.
These compounds have the same murcko framework: 2-(piperidin-4-yl)pyridine.
Alkylation: The piperidine nitrogen can be alkylated using alkyl halides or sulfonates to form N-alkylated derivatives.
Amination: The pyridine ring can be aminated using various amine reagents to introduce amino groups at different positions on the pyridine ring.
Reduction: The pyridine ring can be reduced using reducing agents such as lithium aluminum hydride (LiAlH4) to produce piperidine derivatives.
Substitution reactions: Depending on the conditions and reagents, substitutions can occur on both the pyridine and piperidine rings. Common substitutions include halogenations (e.g., bromination or chlorination) or nucleophilic substitutions.
Oxidation: The compound can undergo oxidation reactions under appropriate conditions to form pyridinium salts or other oxidized products.
Condensation reactions: 2-(piperidin-4-yl)pyridine can participate in condensation reactions to form heterocyclic compounds when reacted with appropriate reagents.
Heterocyclic transformations: Depending on the specific reaction conditions and reagents, it can participate in various heterocyclic transformations, such as ring-opening reactions or cyclization reactions.
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3,5-Dichloro-2-(piperidin-4-yl)pyridine
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2-(Piperidin-4-yl)-6-(trifluoromethyl)pyridine hydrochloride
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tert-Butyl 4-(6-chloropyridin-2-yl)piperidine-1-carboxylate
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tert-Butyl 4-(5-aminopyridin-2-yl)piperidine-1-carboxylate
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tert-Butyl 4-(5-bromopyridin-2-yl)piperidine-1-carboxylate