Chemistry
Heterocyclic Building Blocks
Imidazoles
2-(pyridin-2-yl)-1H-benzo[d]imidazole
Nucleophilic Substitution: The nitrogen atoms in the pyridine and benzimidazole rings are nucleophilic and can undergo substitution reactions with electrophiles. For example, they can react with alkylating agents to introduce alkyl groups at these positions.
Acylation: You can acylate the nitrogen atoms with acyl chlorides or anhydrides to introduce acyl groups.
Halogenation: The aromatic rings can undergo electrophilic aromatic substitution reactions, such as halogenation (e.g., bromination or chlorination) when treated with appropriate reagents.
Cross-Coupling Reactions: You can perform various cross-coupling reactions, such as Suzuki coupling, Heck reaction, or Sonogashira coupling, to introduce other functional groups or molecules onto the benzimidazole or pyridine ring.
Condensation Reactions: 2-(pyridin-2-yl)-1H-benzo[d]imidazole can participate in condensation reactions with various carbonyl compounds or amines to form larger, more complex molecules.
Heterocycle Formation: You can further modify the compound by introducing other heterocyclic rings via various cyclization reactions.
Metalation: Metalation of the nitrogen atoms can be achieved using strong bases or transition metal reagents, allowing for subsequent reactions with various electrophiles.
Functional Group Transformations: Common functional groups like amines, halides, or ketones can be introduced or modified using suitable reagents.
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2-(Pyridin-2-yl)-1H-benzo[d]imidazole-6-carboxylic acid
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2-(1H-Benzo[d]imidazol-2-yl)pyridin-4-amine
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5-Fluoro-2-(pyridin-2-yl)-1H-benzo[d]imidazole