Chemistry Heterocyclic Building Blocks Pyridines 2-(pyridin-2-yl)acetonitrile
Ambeed provide 8 derivatives of 2-(pyridin-2-yl)acetonitrile.
These compounds have the same murcko framework: 2-(pyridin-2-yl)acetonitrileNucleophilic Substitution: The nitrile group can undergo nucleophilic substitution reactions with nucleophiles such as Grignard reagents or primary amines, leading to the formation of corresponding amides or imines, respectively.
Hydrolysis: The nitrile group can be hydrolyzed under acidic or basic conditions to yield the corresponding carboxylic acid or amide, respectively.
Reduction: The nitrile group can be reduced to the corresponding primary amine using reducing agents like lithium aluminum hydride (LiAlH4) or hydrogen gas over a metal catalyst.
Halogenation: The pyridine ring can undergo halogenation reactions, where hydrogen atoms on the ring are replaced by halogen atoms (e.g., bromination or chlorination).
Friedel-Crafts Acylation: The pyridine ring can undergo acylation reactions in the presence of a Lewis acid catalyst, leading to the introduction of an acyl group onto the ring.
Heterocyclization: The compound may undergo heterocyclization reactions, where the nitrogen in the pyridine ring interacts with another functional group to form a new heterocyclic ring system.
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2-(4-(Trifluoromethyl)pyridin-2-yl)acetonitrile
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2-(5-Methylpyridin-2-yl)acetonitrile
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2-(3-Aminopyridin-2-yl)acetonitrile
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2-(4-Fluoropyridin-2-yl)acetonitrile