Chemistry Heterocyclic Building Blocks Pyridines 2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole
Ambeed provide 14 derivatives of 2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole.
These compounds have the same murcko framework: 2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole.
Substitution Reactions: The pyridine moiety can undergo nucleophilic substitution reactions, such as halogenation (e.g., bromination or chlorination) or nucleophilic aromatic substitution.
Oxidation Reactions: Depending on the conditions, the compound can undergo oxidation reactions to form various functional groups. For example, you can oxidize the alcohol in the oxazole ring to a ketone or carboxylic acid.
Reduction Reactions: The oxazole ring can be reduced to a saturated oxazolidine ring using reducing agents like sodium borohydride or lithium aluminum hydride.
Alkylation and Acylation Reactions: The compound can undergo alkylation or acylation reactions at the nitrogen atom in the pyridine ring or the oxygen atom in the oxazole ring.
Cyclization Reactions: Depending on the reaction conditions and reagents, the compound can participate in cyclization reactions to form various heterocyclic compounds.
Amination Reactions: You can introduce amino groups to the compound by using suitable amine sources and reagents, which can be useful for further functionalization.
Cross-Coupling Reactions: The compound can be used in cross-coupling reactions, such as Suzuki-Miyaura, Heck, or Sonogashira reactions, to introduce various substituents onto the pyridine ring.
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(S)-4-Methyl-2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole
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(R)-4-Methyl-2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole
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(R)-4-Isopropyl-2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole
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(S)-4-Isopropyl-2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole
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(R)-4-Isobutyl-2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole
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(S)-4-Isopropyl-2-(2-(pyridin-2-yl)propan-2-yl)-4,5-dihydrooxazole
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(R)-4-(tert-Butyl)-2-(2-(pyridin-2-yl)propan-2-yl)-4,5-dihydrooxazole
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(R)-4-Ethyl-2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole
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2-(Pyridin-2-ylmethyl)-4,5-dihydrooxazole
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(S)-4-((S)-sec-Butyl)-2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole
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(S)-4-(tert-Butyl)-2-(2-(pyridin-2-yl)propan-2-yl)-4,5-dihydrooxazole
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(S)-4-Isobutyl-2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole
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(S)-4-(tert-Butyl)-2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole
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(S)-4-Ethyl-2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole