Chemistry Heterocyclic Building Blocks Pyridines 2-(pyridin-3-yl)acetic acid
Ambeed provide 14 derivatives of 2-(pyridin-3-yl)acetic acid.
These compounds have the same murcko framework: 2-(pyridin-3-yl)acetic acidSubstitution Reactions: The pyridine ring is susceptible to various substitution reactions such as electrophilic aromatic substitution, nucleophilic aromatic substitution, and metal-catalyzed cross-coupling reactions.
Acid-Base Reactions: The carboxylic acid group can undergo acid-base reactions, such as protonation or deprotonation, depending on the pH conditions.
Esterification: The carboxylic acid group can react with alcohols in the presence of acid catalysts to form esters.
Amide Formation: The carboxylic acid group can react with amines to form amides.
Decarboxylation: Under certain conditions, such as heating or catalysis, the carboxylic acid group may undergo decarboxylation, leading to the loss of carbon dioxide and formation of a substituted pyridine derivative.
Reduction: The carboxylic acid group can be reduced to the corresponding alcohol or aldehyde using reducing agents such as lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Oxidation: The compound can be oxidized to various products depending on the reaction conditions, potentially forming ketones, aldehydes, or carboxylic acids.
Halogenation: The pyridine ring can undergo halogenation reactions, such as bromination or chlorination, under appropriate conditions.
Cyclization Reactions: The compound can undergo cyclization reactions under certain conditions, forming cyclic compounds.
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2-(6-(Dimethylamino)pyridin-3-yl)acetic acid hydrochloride
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2-(6-(Trifluoromethyl)pyridin-3-yl)acetic acid
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2-(2-Fluoro-5-methoxypyridin-3-yl)acetic acid
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2-(5-Methylpyridin-3-yl)acetic acid hydrochloride
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2-(6-Chloro-5-methylpyridin-3-yl)acetic acid
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2-(2-Chloro-6-methylpyridin-3-yl)acetic acid