Chemistry Heterocyclic Building Blocks Pyrrolidines 2-(pyrrolidin-1-yl)pyrimidine

2-(pyrrolidin-1-yl)pyrimidine

Ambeed provide 8 derivatives of 2-(pyrrolidin-1-yl)pyrimidine.

These compounds have the same murcko framework: 2-(pyrrolidin-1-yl)pyrimidine.

Nucleophilic Substitution: The pyrrolidine nitrogen can undergo nucleophilic substitution reactions. For example, you can react it with alkyl halides, tosylates, or mesylates to form N-alkylated or N-acylated derivatives.
Acylation: You can react 2-(pyrrolidin-1-yl)pyrimidine with acyl chlorides or anhydrides to introduce acyl groups onto the nitrogen atom.
Oxidation: You can oxidize the compound using strong oxidizing agents to form various oxidation products, depending on reaction conditions.
Reduction: The compound can be reduced with reducing agents to yield different reduced derivatives.
Halogenation: You can halogenate the compound by using halogenating reagents like bromine or chlorine, leading to halogen-substituted products.
Condensation Reactions: It can participate in various condensation reactions with suitable reagents to form heterocyclic compounds or other derivatives.
Cross-Coupling Reactions: You can perform cross-coupling reactions, such as Suzuki, Stille, or Heck reactions, to introduce different substituents at various positions.
Cyclization: Depending on the reaction conditions and reagents, 2-(pyrrolidin-1-yl)pyrimidine can undergo cyclization reactions to form complex ring structures.

Further Reading:
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(3aR,6aS)-octahydrocyclopenta[c]pyrrole (9H-fluoren-9-yl)methyl pyrrolidine-1-carboxylate (R)-1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid (R)-2-benzhydrylpyrrolidine (R)-3-(pyrrolidin-2-yl)pyridine (R)-3-benzylpyrrolidine (R)-3-phenylpyrrolidine (S)-2-benzhydrylpyrrolidine (S)-3-phenylpyrrolidine (S)-N-(((S)-tetrahydro-2H-pyran-2-yl)methyl)pyrrolidine-2-carboxamide (S)-N-(4-(thiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (S)-N-phenethyl-3-(pyrrolidin-2-yl)propanamide 1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid 1-(3-chlorophenyl)pyrrolidine 1-(phenylsulfonyl)pyrrolidine 1-(pyrrolidin-1-yl)ethan-1-one 1-benzyl 2-methyl pyrrolidine-1,2-dicarboxylate 1-benzylpyrrolidin-2-one 1-benzylpyrrolidine 1-methylpyrrolidin-2-one 1-phenylpyrrolidin-2-one 2,2-dimethylpyrrolidine 2,5-dioxopyrrolidin-1-yl ((benzyloxy)carbonyl)glycinate 2,5-dioxopyrrolidin-1-yl benzoate 2,8-diazaspiro[4.5]decan-3-one 2-((3-phenylpropyl)amino)-1-(pyrrolidin-1-yl)ethan-1-one 2-(2-chlorophenyl)pyrrolidine 2-(2-fluorophenyl)pyrrolidine 2-(3-fluorophenyl)pyrrolidine 2-(methoxymethyl)pyrrolidine 2-(pyrrolidin-1-yl)benzoic acid 2-(pyrrolidin-1-yl)pyridine 2-(pyrrolidin-1-yl)pyrimidine 2-(pyrrolidin-2-yl)acetic acid 2-(pyrrolidin-2-yl)pyridine 2-(pyrrolidin-3-yl)acetic acid 2-amino-1-(pyrrolidin-1-yl)ethan-1-one 2-azabicyclo[2.2.1]heptane 2-methyl-1-phenyl-1H-pyrrole 2-methylpyrrolidine 3,3-difluoropyrrolidine 3-(pyrrolidin-2-yl)pyridine 3-aminopyrrolidin-2-one 3-bromopyrrolidine 3-hydroxypyrrolidin-2-one 3-phenoxypyrrolidine 3-phenyl-1-(pyrrolidin-1-yl)propan-1-one 3-phenylpyrrolidine 4-(hydroxymethyl)pyrrolidin-2-one 4-(pyrrolidin-1-yl)aniline 4-(pyrrolidin-1-yl)piperidine 4-hydroxypyrrolidin-2-one 4-phenylpyrrolidin-2-one 4H-thieno[3,4-c]pyrrole-4,6(5H)-dione 5-(aminomethyl)pyrrolidin-2-one 5-(hydroxymethyl)pyrrolidin-2-one 5-azaspiro[2.4]heptane 5-oxopyrrolidine-2-carboxylic acid 6-azaspiro[3.4]octane benzyl (R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate benzyl (R)-3-aminopyrrolidine-1-carboxylate benzyl (S)-pyrrolidin-3-ylcarbamate benzyl 3-hydroxypyrrolidine-1-carboxylate benzyl-2-(hydroxymethyl)pyrrolidine-1-carboxylate benzyl-3-aminopyrrolidine-1-carboxylate ethyl 5-oxopyrrolidine-2-carboxylate hexahydro-1H-pyrrolizine methyl 5-oxopyrrolidine-2-carboxylate methyl prolinate methyl pyrrolidine-3-carboxylate N,N-dimethylpyrrolidin-3-amine N-methylpyrrolidin-3-amine octahydrocyclopenta[c]pyrrole phenyl(pyrrolidin-1-yl)methanone proline pyrrolidin-2-ylmethanamine pyrrolidin-2-ylmethanol pyrrolidin-3-ol pyrrolidin-3-ylmethanamine pyrrolidin-3-ylmethanol pyrrolidine-2-carbonitrile pyrrolidine-2-carboxamide pyrrolidine-3-carbonitrile pyrrolidine-3-carboxylic acid tert-butyl (2-oxopyrrolidin-3-yl)carbamate tert-butyl (5-oxopyrrolidin-3-yl)carbamate tert-butyl 2-oxopyrrolidine-1-carboxylate tert-butyl 3-((methylsulfonyl)oxy)pyrrolidine-1-carboxylate tert-butyl 3-hydroxypyrrolidine-1-carboxylate tert-butyl 3-methoxypyrrolidine-1-carboxylate tert-butyl pyrrolidin-3-ylcarbamate tert-butyl pyrrolidine-1-carboxylate

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(R)-1-amino-2-(methoxymethyl)pyrrolidine (S)-1-amino-2-(methoxymethyl)pyrrolidine 1-(prop-1-en-2-yl)pyrrolidine acetylpyrrolidine aminopyrrolidine benzhydrylpyrrolidine benzylpyrrolidine bipyrrolidine bromopyrrolidine carbamoylpyrrolidine cyanopyrrolidine difluoropyrrolidine dihydroxypyrrolidine dimethylpyrrolidine dioxaborolane-pyrrolidine dioxopyrrolidin ethylpyrrolidine fluoropyrrolidine formylpyrrolidine hydroxypyrrolidine mercaptopyrrolidine methoxypyrrolidine methyl 2-pyrrolidone-5(S)-carboxylate methylenepyrrolidine methylpyrrolidine N-bromosuccinimide N-chlorosuccinimide N-hydroxysuccinimide N-iodosuccinimide N-methyl-2-pyrrolidinone N-phenylmaleimide other-pyrrolidine phenoxypyrrolidine phenylpyrrolidine pyridine-pyrrolidine pyrrolidine-benzene-boronic acid/ester pyrrolidine-carboxylate pyrrolidine-carboxylic acid pyrrolidine-hydrochloride pyrrolidine-methanol pyrrolidine-pyrimidine pyrrolidinone trifluoromethyl-phenyl-pyrrolidine

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