Chemistry Heterocyclic Building Blocks Pyrrolidines 2-(pyrrolidin-2-yl)pyridine
Ambeed provide 5 derivatives of 2-(pyrrolidin-2-yl)pyridine.
These compounds have the same murcko framework: 2-(pyrrolidin-2-yl)pyridine.
Nucleophilic Substitution: If there is a leaving group attached to the pyridine ring, you can perform nucleophilic substitution reactions. For example, you could replace a leaving group with another nucleophile.
Acylation: You can acylate the nitrogen atom in the pyrrolidine ring using acyl chlorides or anhydrides to introduce acyl groups.
Reductive Amination: You can perform reductive amination by reacting 2-(pyrrolidin-2-yl)pyridine with an amine and a reducing agent to introduce new amine groups.
Oxidation: The pyridine ring can undergo oxidation reactions to convert it into a different functional group, such as pyridine N-oxide.
Ring Opening Reactions: Depending on the conditions, you can induce ring-opening reactions of the pyrrolidine ring to form open-chain compounds or other cyclic structures.
Metal-Catalyzed Reactions: You can use transition metal catalysts to facilitate various reactions, such as cross-coupling reactions, C-H activation, and more.
Halogenation: You can halogenate the pyridine or pyrrolidine ring by using halogenating agents.
N-Heterocyclic Carbene Formation: Under appropriate conditions, 2-(pyrrolidin-2-yl)pyridine can be used as a precursor to create N-heterocyclic carbenes (NHCs), which are important ligands in organometallic chemistry.
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5-Bromo-2-(pyrrolidin-2-yl)pyridine
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4-Chloro-2-(pyrrolidin-2-yl)pyridine dihydrochloride
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5-Bromo-2-(pyrrolidin-2-yl)pyridine dihydrochloride