Chemistry Heterocyclic Building Blocks Thiophenes 2-(thiophen-2-yl)pyridine

2-(thiophen-2-yl)pyridine

Ambeed provide 5 derivatives of 2-(thiophen-2-yl)pyridine.

These compounds have the same murcko framework: 2-(thiophen-2-yl)pyridine.

Arylation or Alkylation: You can introduce substituents to the pyridine ring through electrophilic aromatic substitution. For example, you can react 2-(thiophen-2-yl)pyridine with aryl or alkyl halides in the presence of a suitable base or transition metal catalyst to add substituents to the pyridine ring.
Halogenation: 2-(thiophen-2-yl)pyridine can undergo halogenation reactions with halogenating agents like bromine or chlorine to introduce halogen atoms to the molecule.
Reduction: Reduction of the pyridine or thiophene ring can be achieved with reducing agents like hydrogen gas (catalytic hydrogenation) or with chemical reducing agents like lithium aluminum hydride (LiAlH4).
Oxidation: Oxidation of 2-(thiophen-2-yl)pyridine can be carried out with various oxidizing agents to convert it to the corresponding oxidation product.
Grignard Reaction: 2-(thiophen-2-yl)pyridine can react with Grignard reagents, which are organomagnesium compounds, to form new carbon-carbon bonds and introduce various functional groups.
Cross-Coupling Reactions: It can participate in various cross-coupling reactions like Suzuki-Miyaura, Heck, or Sonogashira reactions to form C-C bonds with other organic compounds.
Substitution Reactions: 2-(thiophen-2-yl)pyridine can undergo nucleophilic substitution reactions, especially with electrophilic functional groups.

Further Reading:
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Purity
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Conditions to empty

Framework+−

(9H-fluoren-9-yl)methyl (2-(thiophen-2-yl)ethyl)carbamate 1-(thiophen-2-yl)ethan-1-one 2,2'-bithiophene 2,2':5',2''-terthiophene 2,3-dihydrothieno[3,4-b][1,4]dioxine 2,5-dibromothiophene 2,5-diphenylthiophene 2-(thiophen-2-yl)pyridine 2-(trifluoromethyl)thiophene 2-chlorothiophene 2-ethynylthiophene 2-iodothiophene 2-methoxythiophene 2-nitrothiophene 3-bromothiophene 3-chlorothiophene 3-fluorothiophene 3-methoxythiophene 3-methylthiophene 3-nitrothiophene 3-phenylthiophene 4,4,5,5-tetramethyl-2-(thiophen-2-yl)-1,3,2-dioxaborolane 4,4,5,5-tetramethyl-2-(thiophen-3-yl)-1,3,2-dioxaborolane 4,5,6,7-tetrahydrothieno[2,3-c]pyridine 4,5,6,7-tetrahydrothieno[3,2-c]pyridine 4,7-di(thiophen-2-yl)benzo[c][1,2,5]thiadiazole 4,8-di(thiophen-2-yl)benzo[1,2-b:4,5-b']dithiophene 4-phenyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine 4H-cyclopenta[2,1-b:3,4-b']dithiophene 4H-thieno[3,2-b]pyrrole 4H-thieno[3,4-c]pyrrole-4,6(5H)-dione 5,6-dihydro-4H-cyclopenta[b]thiophene 5-(thiophen-2-yl)isoxazole 5-benzyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine 5-phenylthiophen-2-amine benzo[1,2-b:4,5-b']dithiophene dibenzo[b,d]thiophene dihydrothiophen-3(2H)-one dithieno[3,2-b:2',3'-d]thiophene ethyl thiophene-2-carboxylate ethyl thiophene-3-carboxylate methyl thiophene-3-carboxylate N,N-diphenyl-4-(thiophen-2-yl)aniline phenyl(thiophen-2-yl)methanone thieno[2,3-b]pyridine thieno[2,3-c]pyridine thieno[2,3-d]pyrimidine thieno[3,2-b]pyridine thieno[3,2-b]thiophene thieno[3,2-c]pyridine thieno[3,2-d]pyrimidine thieno[3,4-b]thiophene thiophen-2-ylboronic acid thiophen-2-ylmethanol thiophen-3-amine thiophen-3-ol thiophen-amine-hydrochloride thiophene-2-carbaldehyde thiophene-2-carbonitrile thiophene-3-carbaldehyde thiophene-3-carbonitrile thiophene-3-carboxamide thiophene-3-carboxylic acid

By Key Group+−

2-thienyl acetylthiophene aminothiophene bithiophene bromothieno bromothiophene chlorothieno chlorothiophene cyanothiophene dibromothieno dibromothiophene dichlorothieno dichlorothiophene dihydrothieno dihydrothiophene dihydroxythiophene dimethylthieno dimethylthiophene dithiophene fluorothiophene formylthiophene hydroxythiophene iodothieno iodothiophene methoxythiophene methylthieno methylthiophene nitrothiophene oxotetrahydrothiophene terthiophene tetrahydrothieno thieno-pyrrole thienoimidazol thienopyridine thienopyrimidine thienothiophene thienyl-benzene-boronic acid/ester thiophen-ethanamine thiophene-boronic acid thiophene-hydrochloride thiophenecarbonitrile thiophenecarboxaldehyde thiophenecarboxylic thiopheno-nitrile trifluoromethyl-benzothiophene trifluoromethyl-thiophene trithiophene

cLogP+−

H-Acceptors+−

H-Donors+−

Polar Surface Area+−

Druglikeness+−

NNCH/NNH+−

sp3-Atoms+−

Non-Aromatic Rings+−

Aromatic Rings+−

Rotatable Bonds+−

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