Chemistry Heterocyclic Building Blocks Pyridines 2-(tributylstannyl)pyridine
Cross-coupling reactions: It can undergo palladium-catalyzed cross-coupling reactions with aryl halides or vinyl halides to form C-C bonds. This is a widely used method for synthesizing biaryl compounds and functionalized pyridines.
Nucleophilic substitution reactions: The pyridyl anion generated from 2-(tributylstannyl)pyridine can undergo nucleophilic substitution reactions with electrophiles, such as alkyl halides or acyl chlorides, leading to functionalized pyridine derivatives.
Metalation reactions: The pyridyl anion can undergo metalation reactions with various electrophiles, such as alkyl halides, aryl halides, or organolithium compounds, to generate new carbon-metal bonds.
Cyclization reactions: It can participate in cyclization reactions, such as Suzuki-Miyaura cyclization, Sonogashira cyclization, or Heck cyclization, leading to the formation of heterocyclic compounds.
Reductive reactions: 2-(tributylstannyl)pyridine can undergo reductive transformations, such as reduction with hydride reagents or metal hydrides, to afford functionalized pyridine derivatives.
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