Chemistry Heterocyclic Building Blocks Pyridines 2-(trifluoromethyl)pyridine
Ambeed provide 6 derivatives of 2-(trifluoromethyl)pyridine.
These compounds have the same murcko framework: 2-(trifluoromethyl)pyridineNucleophilic substitution reactions: The CF3 group can be replaced by a nucleophile, leading to the formation of new C-N bonds.
Electrophilic aromatic substitution reactions: The electron-rich pyridine ring can undergo substitution reactions with electrophiles at various positions, such as ortho, meta, or para to the CF3 group.
Metal-catalyzed reactions: CF3-pyridine can participate in metal-catalyzed reactions such as cross-coupling reactions, where the CF3 group can be transferred to another organic moiety.
Oxidation reactions: CF3-pyridine can undergo oxidation reactions to form various functionalized products.
Reduction reactions: Reduction of the CF3 group or the pyridine ring can occur under appropriate conditions, yielding different products.
Addition reactions: CF3-pyridine can participate in addition reactions with suitable reagents, leading to the addition of functional groups onto the pyridine ring or the CF3 group itself.
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6-Hydroxy-2-(trifluoromethyl)nicotinic acid
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2-Hydroxy-6-trifluoromethylnicotinic acid
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1-(2-Hydroxy-6-(trifluoromethyl)pyridin-3-yl)ethanone
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3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol