Chemistry Heterocyclic Building Blocks Pyrimidines 2-(trifluoromethyl)pyrimidine
Ambeed provide 27 derivatives of 2-(trifluoromethyl)pyrimidine.
These compounds have the same murcko framework: 2-(trifluoromethyl)pyrimidineNucleophilic Substitution: The pyrimidine ring can undergo nucleophilic substitution reactions. For example, the trifluoromethyl group could be replaced by a nucleophile under appropriate conditions.
Arylation Reactions: The trifluoromethyl group can participate in various arylation reactions. It may act as an electrophile in the presence of appropriate nucleophiles or metal catalysts.
Cross-Coupling Reactions: The compound may participate in cross-coupling reactions, such as Suzuki-Miyaura or Heck reactions, where the trifluoromethyl group can be involved in the coupling with another organic moiety.
Halogenation Reactions: The pyrimidine ring can undergo halogenation reactions, where hydrogen atoms on the ring are replaced by halogen atoms.
Reduction Reactions: The trifluoromethyl group may be subject to reduction reactions, converting it to a methyl group or another substituent.
N-Heterocyclic Carbene Formation: The nitrogen atom in the pyrimidine ring may participate in the formation of N-heterocyclic carbenes, a class of compounds often used in organometallic chemistry.
Functional Group Interconversion: Various functional group interconversion reactions may be possible, depending on the specific conditions. For example, the trifluoromethyl group might be converted into a different functional group.
Metalation Reactions: The pyrimidine ring may undergo metalation reactions, where a metal atom is introduced onto the ring, rendering it more reactive towards other species.
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1-(2-(Trifluoromethyl)pyrimidin-5-yl)ethanone
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5-Chloro-2-(trifluoromethyl)pyrimidine
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6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine
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6-Chloro-N,N-dimethyl-2-(trifluoromethyl)pyrimidin-4-amine
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Ethyl 4-chloro-2-trifluoromethylpyrimidine-5-carboxylate
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2-(Trifluoromethyl)pyrimidine-5-carbaldehyde
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3-(2-(Trifluoromethyl)pyrimidin-5-yl)propanoic acid
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4,6-Dibromo-2-(trifluoromethyl)pyrimidine
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4-Chloro-6-methyl-2-trifluoromethylpyrimidine
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(2-(Trifluoromethyl)pyrimidin-5-yl)boronic acid
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Ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate
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Ethyl 2-(2-(trifluoromethyl)pyrimidin-5-yl)acetate
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4-Methyl-2-(trifluoromethyl)pyrimidine-5-carboxylic acid
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(2-(Trifluoromethyl)pyrimidin-5-yl)methanol
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4-Methyl-2-(trifluoromethyl)pyrimidine
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2-(Trifluoromethyl)pyrimidine-5-carboxylic acid
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Ethyl 4-hydroxy-2-(trifluoromethyl)pyrimidine-5-carboxylate