Chemistry Heterocyclic Building Blocks Pyridines 2-aminonicotinonitrile
Ambeed provide 6 derivatives of 2-aminonicotinonitrile.
These compounds have the same murcko framework: 2-aminonicotinonitrileSubstitution Reactions: The amino group (-NH2) can undergo substitution reactions with electrophiles, such as acyl chlorides, acid anhydrides, or alkyl halides, to form amides, imides, or alkylated amines, respectively.
Addition Reactions: The nitrile group (-CN) can undergo addition reactions, for instance, with hydrogen cyanide (HCN) to form aminonitriles, or with Grignard reagents to yield substituted amines.
Ring-closure Reactions: Depending on the reaction conditions and the presence of suitable functional groups, ring-closure reactions can occur to form heterocyclic compounds, such as pyridines or pyrimidines.
Reduction Reactions: The nitrile group can be reduced to the corresponding primary amine under certain conditions, such as with reducing agents like lithium aluminum hydride (LiAlH4) or catalytic hydrogenation.
Oxidation Reactions: The amino group can be oxidized to form various functional groups, such as nitro groups (-NO2)or oximes (-C=N-OH), depending on the oxidizing agent and reaction conditions.
Condensation Reactions: It can undergo condensation reactions with carbonyl compounds, such as aldehydes or ketones, to form Schiff bases or imines.
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2-Amino-4-(dimethylamino)nicotinonitrile