Chemistry Heterocyclic Building Blocks Pyridines 2-benzylpyridine
Ambeed provide 12 derivatives of 2-benzylpyridine.
These compounds have the same murcko framework: 2-benzylpyridine.
Acylation: 2-benzylpyridine can undergo acylation reactions, where an acyl group (-COR) is added to the nitrogen atom in the pyridine ring. This can be achieved using acylating agents such as acyl chlorides or anhydrides in the presence of a base like pyridine.
Alkylation: It can also undergo alkylation reactions where alkyl groups (-CH3, -C2H5, etc.) are introduced onto the nitrogen atom or other positions in the pyridine ring. This typically requires the use of alkylating agents such as alkyl halides and a base.
Reduction: 2-benzylpyridine can be reduced to form 2-methylpyridine, also known as 2-picoline. Common reducing agents like sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4) can be employed for this purpose.
Oxidation: Under appropriate conditions, 2-benzylpyridine can be oxidized to form various products. Oxidizing agents like potassium permanganate (KMnO4) or chromic acid (H2CrO4) can be used for this purpose.
Grignard Reaction: 2-benzylpyridine can react with a Grignard reagent (RMgX) to form a new compound through nucleophilic addition. This reaction can introduce various functional groups onto the benzylpyridine molecule.
Halogenation: 2-benzylpyridine can undergo halogenation reactions, where halogen atoms (e.g., Cl, Br) are added to the benzyl or pyridine ring. This can be achieved using halogenating agents such as N-bromosuccinimide (NBS) or chlorine gas.
Nucleophilic Substitution: Depending on the conditions, 2-benzylpyridine can undergo nucleophilic substitution reactions at various positions on the molecule, especially the benzyl group or the pyridine ring.
Heterocyclic Chemistry: 2-benzylpyridine can participate in various heterocyclic chemistry reactions, including the synthesis of more complex heterocyclic compounds.
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(S)-(4-Chlorophenyl)(pyridin-2-yl)methanol