Chemistry
Organic Building Blocks
Bromides
2-bromo-1,4-difluorobenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —Br,—F).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
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2-(2-Bromo-3,6-difluorophenyl)acetic acid
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1-Bromo-2,5-difluoro-4-(trifluoromethoxy)benzene
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2-(4-Bromo-2,5-difluorophenyl)acetic acid
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1-Bromo-2,5-difluoro-4-(trifluoromethyl)benzene
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1-Bromo-2,3,4,5-tetrafluoro-6-nitrobenzene