Chemistry Organic Building Blocks Bromides 2-bromo-1-chloro-3-fluorobenzene
Ambeed provide 7 derivatives of 2-bromo-1-chloro-3-fluorobenzene.
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—Cl,—F).
Electrophilic Aromatic Substitution (EAS): Bromobenzene can react with electrophiles in substitution reactions, such as nitration, sulfonation, halogenation, and Friedel-Crafts acylation/alkylation.
Grignard Reaction: Chlorobenzene can react with magnesium metal to form phenylmagnesium chloride, which can then react with various electrophiles to introduce new functional groups onto the aromatic ring.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
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3-Bromo-2,6-dichloro-4-fluorophenol
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2,5-Dibromo-1-chloro-3-fluorobenzene
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2-Amino-4-bromo-5-chloro-3-fluorobenzoic acid