Chemistry
Organic Building Blocks
Bromides
2-bromo-1-chloro-4-methylbenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—Cl,—CH3).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Sandmeyer Reaction: Chlorobenzene can be converted to other aryl halides through the Sandmeyer reaction, involving replacement of the chlorine atom with other halogens.
Sulfonation: Toluene can be sulfonated, leading to the introduction of a sulfonic acid group (-SO3H) onto the benzene ring. This is often carried out using concentrated sulfuric acid.
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