Chemistry Organic Building Blocks Bromides 2-bromo-1-fluoro-3-nitrobenzene
Ambeed provide 4 derivatives of 2-bromo-1-fluoro-3-nitrobenzene.
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—F,—NO2).
Electrophilic Aromatic Substitution (EAS): Bromobenzene can react with electrophiles in substitution reactions, such as nitration, sulfonation, halogenation, and Friedel-Crafts acylation/alkylation.
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
Reduction: The nitro group in nitrobenzene can be reduced to an amino group (-NH2) using reducing agents like iron and hydrochloric acid, or more commonly, using catalytic hydrogenation. This reaction produces aniline.
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2,4-Dibromo-1,5-difluoro-3-nitrobenzene
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2-Bromo-1,5-difluoro-3-nitrobenzene
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1,4-Dibromo-2,3-difluoro-5,6-dinitrobenzene