Chemistry Heterocyclic Building Blocks Pyridines 2-bromo-3-(trifluoromethyl)pyridine
Ambeed provide 4 derivatives of 2-bromo-3-(trifluoromethyl)pyridine.
These compounds have the same murcko framework: 2-bromo-3-(trifluoromethyl)pyridineNucleophilic substitution: The bromine atom can be substituted by a nucleophile, such as an amine or a thiol, leading to the formation of a new compound.
Palladium-catalyzed coupling reactions: The trifluoromethyl group can participate in cross-coupling reactions with various organic substrates under palladium catalysis, such as Suzuki, Heck, or Sonogashira reactions.
Electrophilic aromatic substitution: The electron-rich pyridine ring can undergo electrophilic aromatic substitution reactions, where electrophiles attack the aromatic ring, substituting a hydrogen atom. This can lead to the introduction of various functional groups onto the pyridine ring.
Reductive reactions: The bromine atom can be reduced to a different functional group, such as an alkyl group, under appropriate reaction conditions.
Radical reactions: The bromine atom can undergo radical reactions, such as radical halogenation or radical coupling reactions, leading to the formation of new carbon-carbon or carbon-heteroatom bonds.
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Methyl 3-amino-6-bromo-5-(trifluoromethyl)picolinate
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6-Bromo-5-(trifluoromethyl)pyridin-3-amine
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6-Bromo-5-(trifluoromethyl)nicotinonitrile