Chemistry Heterocyclic Building Blocks Pyridines 2-bromo-3-iodopyridine
Ambeed provide 6 derivatives of 2-bromo-3-iodopyridine.
These compounds have the same murcko framework: 2-bromo-3-iodopyridineSubstitution Reactions: The halogens (bromine and iodine) in 2-bromo-3-iodopyridine can be substituted by other functional groups or atoms under appropriate conditions. For example, nucleophilic aromatic substitution reactions can occur, where the bromine or iodine atom is replaced by a nucleophile such as hydroxide, amine, or thiol.
Cross-Coupling Reactions: 2-bromo-3-iodopyridine can participate in cross-coupling reactions, particularly palladium-catalyzed coupling reactions such as Suzuki coupling, Stille coupling, or Heck reaction. These reactions involve the formation of a new carbon-carbon bond between the pyridine ring and another organic substrate.
Reduction Reactions: The bromine and iodine atoms in 2-bromo-3-iodopyridine can be selectively reduced to corresponding organometallic compounds or substituted with hydrogen atoms under appropriate reducing conditions.
Metalation Reactions: The pyridine ring in 2-bromo-3-iodopyridine can undergo metalation reactions with strong bases to form metal complexes. These metal complexes can further participate in various organic transformations or catalytic reactions.
Halogen Exchange Reactions: 2-bromo-3-iodopyridine can undergo halogen exchange reactions with other halogen-containing compounds under suitable conditions, leading to the formation of different halogenated pyridine derivatives.
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2-Bromo-3-iodo-5-(trifluoromethyl)pyridine