Chemistry Heterocyclic Building Blocks Pyridines 2-bromo-3-methoxypyridine
Ambeed provide 7 derivatives of 2-bromo-3-methoxypyridine.
These compounds have the same murcko framework: 2-bromo-3-methoxypyridineSubstitution Reactions: Since 2-bromo-3-methoxypyridine contains a bromine atom, it can undergo substitution reactions where the bromine atom is replaced by another functional group. This can include nucleophilic substitution reactions with various nucleophiles.
Cross-Coupling Reactions: 2-Bromo-3-methoxypyridine can undergo cross-coupling reactions, such as Suzuki coupling, Stille coupling, or Heck coupling, to form biaryl compounds or other substituted pyridines.
Nucleophilic Aromatic Substitution (SNAr): The presence of a bromine atom makes 2-bromo-3-methoxypyridine susceptible to SNAr reactions, where a nucleophile substitutes the bromine atom on the aromatic ring.
Metalation Reactions: The pyridine ring can be metalated with strong bases, such as butyllithium or LDA (lithium diisopropylamide), followed by reaction with various electrophiles to introduce new functional groups.
Reductive Reactions: 2-Bromo-3-methoxypyridine can undergo reductive reactions where the bromine atom is replaced by a hydrogen atom, usually using strong reducing agents like lithium aluminum hydride (LiAlH4) or pyridine-catalyzed hydrogenation.
Functional Group Transformations: Various functional group transformations can be carried out on 2-bromo-3-methoxypyridine, including oxidation, reduction, and addition reactions.
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Methyl 6-bromo-5-methoxypicolinate