Chemistry Heterocyclic Building Blocks Pyridines 2-bromo-3-methylpyridine
Substitution Reactions: The bromine atom can be substituted with other nucleophiles or functional groups, such as amines, alcohols, or thiols, through nucleophilic substitution reactions.
Metalation Reactions: The pyridine ring can be metalated using strong bases such as butyl lithium or sodium amide, leading to the formation of organometallic compounds.
Nucleophilic Aromatic Substitution (SNAr): The electron-deficient pyridine ring can undergo nucleophilic aromatic substitution reactions, where the bromine atom serves as the leaving group and is replaced by a nucleophile.
Cross-Coupling Reactions: The bromine atom can participate in palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, or Stille coupling, enabling the synthesis of more complex molecules.
Reductive Reactions: The bromine atom can be selectively reduced to introduce a hydrogen atom or another functional group using reducing agents like lithium aluminum hydride (LiAlH4) or hydrogen gas over a metal catalyst.
Functional Group Transformations: The methyl group can undergo various transformations such as oxidation, reduction, or substitution reactions depending on the reagents and conditions used.
Ring Closure Reactions: Depending on the reaction conditions and reagents, ring closure reactions can occur, leading to the formation of heterocyclic compounds or fused ring systems.
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2-Bromo-4-methoxy-3,5-dimethylpyridine
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2-Bromo-3-methyl-4-(trifluoromethyl)pyridine
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(6-Bromo-5-methylpyridin-3-yl)boronic acid