Chemistry Organic Building Blocks Bromides 2-bromo-4-chloro-1-methoxybenzene
Ambeed provide 3 derivatives of 2-bromo-4-chloro-1-methoxybenzene.
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—OCH3,—Cl).
Grignard Reaction: Bromobenzene can react with a Grignard reagent (organomagnesium compound) to form a new carbon-carbon bond, leading to the introduction of various functional groups.
Borohydride Demethylation: Methoxybenzene can undergo demethylation reactions using sodium borohydride (NaBH4) in the presence of a proton source, resulting in the formation of phenol.
Electrophilic Substitution Reactions: Chlorobenzene's electron-rich aromatic ring can undergo substitution reactions where a hydrogen atom is replaced by a chlorine atom. For instance, it can undergo nitration, sulfonation, and Friedel-Crafts alkylation/acylation reactions.
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(2-Bromo-6-chloro-3-methoxyphenyl)boronic acid
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(3-Bromo-5-chloro-2-methoxyphenyl)boronic acid