Chemistry Heterocyclic Building Blocks Pyridines 2-bromo-4-chloropyridine
Nucleophilic substitution: The bromine and chlorine atoms in 2-bromo-4-chloropyridine are susceptible to substitution reactions with nucleophiles. For example, reaction with a strong nucleophile like a Grignard reagent could lead to the replacement of bromine or chlorine with the nucleophile.
Metalation: The pyridine ring in 2-bromo-4-chloropyridine can undergo metalation reactions with strong bases or metal reagents, leading to the formation of metal complexes.
Cross-coupling reactions: 2-bromo-4-chloropyridine can participate in cross-coupling reactions, such as Suzuki, Stille, or Heck reactions, where it can react with suitable partners under palladium catalysis to form biaryl compounds or other products.
Reduction reactions: The bromine and chlorine atoms can be selectively reduced to other functional groups, such as alkyl groups, using appropriate reducing agents.
Electrophilic aromatic substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions under appropriate conditions, leading to substitution at the aromatic ring.
Functional group transformations: The bromine and chlorine atoms can be converted into other functional groups through various chemical transformations, such as oxidation or substitution reactions.
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1-(6-Bromo-4-chloropyridin-2-yl)ethanone
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1-(2-Bromo-4-chloropyridin-3-yl)ethanone