Chemistry Organic Building Blocks Bromides 2-bromo-4-fluoro-1-methylbenzene
Ambeed provide 21 derivatives of 2-bromo-4-fluoro-1-methylbenzene.
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—CH3,—F).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal alkynes using a palladium catalyst, leading to the formation of substituted alkynes.
Sulfonation: Toluene can be sulfonated, leading to the introduction of a sulfonic acid group (-SO3H) onto the benzene ring. This is often carried out using concentrated sulfuric acid.
Metalation Reactions: Fluorobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
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(2-Bromo-6-fluoro-3-methylphenyl)boronic acid
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2-Bromo-6-fluoro-3-methylbenzoic acid
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1-(2-Bromo-6-fluoro-3-methylphenyl)ethanone
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3-Bromo-5-fluoro-2-methyl-benzoic acid methyl ester
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(4-Bromo-2-fluoro-5-methylphenyl)boronic acid
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1-Bromo-4-chloro-5-fluoro-2-methylbenzene
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2-Bromo-6-fluoro-3-methylbenzonitrile