Chemistry Organic Building Blocks Bromides 2-bromo-4-fluorobenzoic acid
Ambeed provide 5 derivatives of 2-bromo-4-fluorobenzoic acid.
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—COOH,—F).
Grignard Reaction: Bromobenzene can react with a Grignard reagent (organomagnesium compound) to form a new carbon-carbon bond, leading to the introduction of various functional groups.
Decarboxylation: Under certain conditions, benzoic acid can undergo decarboxylation, where it loses a carbon dioxide molecule from its carboxylic acid group. This reaction usually requires high temperatures and is often observed in the presence of strong acids or bases.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
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2-Bromo-4-fluoro-5-nitrobenzoic acid
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2-Bromo-4-fluoro-5-methylbenzoic acid