Chemistry
Organic Building Blocks
Bromides
2-bromo-4-fluorophenol
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—OH,—F).
Suzuki-Miyaura Coupling: Bromobenzene can participate in cross-coupling reactions with organoboron compounds in the presence of a palladium catalyst, resulting in the formation of biaryl compounds.
Fries Rearrangement: Phenol can undergo the Fries rearrangement when treated with a Lewis acid catalyst, leading to the migration of an acyl group within the molecule.
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
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(2-Bromo-6-fluoro-3-hydroxyphenyl)boronic acid
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2-Bromo-4-fluoro-5-(trifluoromethyl)phenol