Chemistry Heterocyclic Building Blocks Pyridines 2-bromo-4-methylpyridine
Ambeed provide 6 derivatives of 2-bromo-4-methylpyridine.
These compounds have the same murcko framework: 2-bromo-4-methylpyridineSubstitution Reactions: The bromine atom on the pyridine ring can be substituted with other functional groups through nucleophilic aromatic substitution (SNAr) reactions. For example, substitution with a nucleophile like a primary amine can yield an N-alkylated or N-aryl pyridine.
Metalation Reactions: The bromine atom can be replaced with a metal atom using appropriate metalation reagents. This can lead to the formation of organometallic complexes which can further participate in various reactions.
Cross-Coupling Reactions: The bromine atom can undergo palladium-catalyzed cross-coupling reactions such as Suzuki, Heck, or Stille coupling, enabling the synthesis of biaryl compounds or other functionalized pyridines.
Reduction Reactions: The bromine atom can be reduced to an alkyl group or a hydrogen atom using reducing agents like lithium aluminum hydride (LiAlH4) or hydrogen gas over a metal catalyst.
Oxidation Reactions: The methyl group or the pyridine ring can undergo oxidation reactions to yield corresponding ketones, aldehydes, or carboxylic acids.
Ring-Closure Reactions: Under suitable conditions, it can participate in ring-closure reactions leading to the formation of heterocyclic compounds.
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1-(6-Bromo-4-methylpyridin-3-yl)ethan-1-one
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Ethyl 2-bromo-4-methylpyridine-3-carboxylate
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2-Bromo-5-(difluoromethyl)-4-methylpyridine