Chemistry
Organic Building Blocks
Bromides
2-bromo-4-nitroaniline
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—NH2,—NO2).
Electrophilic Aromatic Substitution (EAS): Bromobenzene can react with electrophiles in substitution reactions, such as nitration, sulfonation, halogenation, and Friedel-Crafts acylation/alkylation.
Reimer-Tiemann Reaction: Aniline can react with chloroform (CHCl3) and a base to undergo the Reimer-Tiemann reaction, leading to the formation of a salicylaldehyde derivative.
Reduction: The nitro group in nitrobenzene can be reduced to an amino group (-NH2) using reducing agents like iron and hydrochloric acid, or more commonly, using catalytic hydrogenation. This reaction produces aniline.
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Methyl 5-amino-4-bromo-2-nitrobenzoate
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2-Bromo-4-nitro-5-(trifluoromethyl)aniline