Chemistry Heterocyclic Building Blocks Pyridines 2-bromo-5-fluoropyridine
Nucleophilic substitution: The bromine atom is often a site for substitution reactions, where a nucleophile replaces the bromine atom. This could involve reactions with amines, thiols, or other nucleophiles.
Metal-catalyzed cross-coupling reactions: The bromo and fluoro substituents make 2-bromo-5-fluoropyridine suitable for metal-catalyzed cross-coupling reactions such as Suzuki, Stille, or Heck reactions.
Electrophilic substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions where electrophiles substitute for hydrogen atoms on the ring. This could include reactions like Friedel-Crafts acylation or Friedel-Crafts alkylation.
Reductive reactions: The bromo or fluoro substituents can be reduced to other functional groups using appropriate reducing agents.
Functional group interconversion: Various functional groups can be introduced or modified through appropriate reactions, including oxidation, reduction, and functional group interconversion reactions.
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2-Bromo-4-(difluoromethyl)-5-fluoropyridine
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(2-Bromo-5-fluoropyridin-4-yl)boronic acid
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2-Bromo-5-fluoro-4-pyridinecarboxylic acid
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2-Bromo-5-fluoro-4-(trifluoromethyl)pyridine
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Methyl 2-bromo-5-fluoropyridine-4-carboxylate
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2-Bromo-4-(difluoromethoxy)-5-fluoropyridine
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tert-Butyl (2-bromo-5-fluoropyridin-4-yl)carbamate
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6-Bromo-3-fluoropyridine-2-carbaldehyde
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(2-Bromo-5-fluoropyridin-3-yl)methanamine hydrochloride