Chemistry Heterocyclic Building Blocks Pyridines 2-bromo-5-methoxypyridine
Ambeed provide 11 derivatives of 2-bromo-5-methoxypyridine.
These compounds have the same murcko framework: 2-bromo-5-methoxypyridineSubstitution reactions: Since it has a bromine atom, it can undergo substitution reactions where the bromine is replaced by another group or atom. For example, substitution with nucleophiles like amines, thiols, or cyanide ions can occur.
Cross-coupling reactions: It can participate in various cross-coupling reactions such as Suzuki coupling, Stille coupling, or Heck reaction. These reactions typically involve coupling the pyridine ring with an organometallic reagent to form a new carbon-carbon bond.
Nucleophilic aromatic substitution (SNAr): Given its electron-deficient nature due to the presence of the bromine atom, it can undergo nucleophilic aromatic substitution reactions where the bromine atom is replaced by a nucleophile, such as an amine, alcoholate, or cyanide ion.
Metalation reactions: 2-bromo-5-methoxypyridine can undergo metalation reactions with strong bases to generate pyridine derivatives with metal substituents.
Reduction reactions: It can undergo reduction reactions to convert the bromine functionality to other functional groups. For instance, reduction with strong reducing agents like lithium aluminum hydride (LiAlH4) or hydrogenation with a metal catalyst can lead to the formation of corresponding substituted pyridine derivatives.
Halogenation reactions: It can undergo halogenation reactions to introduce other halogen atoms onto the pyridine ring, provided suitable conditions and reagents are used.
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2-Bromo-5-methoxyisonicotinic acid
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(2-Bromo-5-methoxypyridin-4-yl)boronic acid