Chemistry Heterocyclic Building Blocks Pyridines 2-bromo-5-methylpyridine
Ambeed provide 19 derivatives of 2-bromo-5-methylpyridine.
These compounds have the same murcko framework: 2-bromo-5-methylpyridineNucleophilic substitution: The bromine atom is a good leaving group, so 2-bromo-5-methylpyridine can undergo nucleophilic substitution reactions with nucleophiles such as hydroxide ions, amines, or thiolates to replace the bromine atom with the nucleophile.
Metalation: The pyridine ring can be metalated at the 2-position or 5-position using strong bases such as butyllithium or sodium amide, resulting in the formation of metal pyridine complexes.
Cross-coupling reactions: 2-bromo-5-methylpyridine can participate in cross-coupling reactions such as Suzuki-Miyaura coupling or Stille coupling to form carbon-carbon bonds with various organic electrophiles.
Reductive reactions: The bromine atom can be replaced with a hydrogen atom through reductive reactions using reducing agents such as lithium aluminum hydride or hydrogen gas over a catalyst.
Oxidative reactions: 2-bromo-5-methylpyridine can undergo oxidation reactions to form pyridine N-oxide or other oxidized derivatives under appropriate conditions.
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6-Bromo-3-methyl-pyridine-2-carboxylic acid methyl ester