Chemistry
Organic Building Blocks
Bromides
2-bromo-6-fluorobenzonitrile
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—C≡N,—F).
Grignard Reaction: Bromobenzene can react with a Grignard reagent (organomagnesium compound) to form a new carbon-carbon bond, leading to the introduction of various functional groups.
Cyanation and Cyanation Reactions: The cyano group in benzonitrile can serve as a nucleophile in various reactions, leading to the introduction of cyano groups onto other molecules.
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
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2-Bromo-6-fluoro-3-methylbenzonitrile