Chemistry Heterocyclic Building Blocks Pyridines 2-bromopyridine 1-oxide
Ambeed provide 6 derivatives of 2-bromopyridine 1-oxide.
These compounds have the same murcko framework: 2-bromopyridine 1-oxideNucleophilic Substitution: The bromine atom can undergo nucleophilic substitution reactions, where it can be replaced by a nucleophile such as a hydroxide ion, amine, or thiolate ion. This could lead to the formation of corresponding substituted pyridines.
Oxidation: The oxygen atom in the pyridine ring can undergo oxidation reactions, leading to the formation of various oxygen-containing functional groups such as ketones, alcohols, or carboxylic acids.
Reduction: Conversely, the oxygen atom can be reduced to a hydroxyl group or further to a methylene group, depending on the reducing conditions.
Metalation: The pyridine ring can be metalated at the 2-position by treatment with strong bases and metal salts, leading to the formation of organometallic complexes.
Cross-Coupling Reactions: The bromine atom can undergo cross-coupling reactions with various coupling partners such as aryl or vinyl boronic acids, leading to the formation of biaryl or vinylic compounds.
Ring Closure Reactions: Under appropriate conditions, 2-bromopyridine 1-oxide can undergo ring closure reactions to form cyclic compounds.
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2-Bromo-5-fluoro-4-nitropyridine 1-oxide