Chemistry Heterocyclic Building Blocks Pyridines 2-bromopyridine
Ambeed provide 10 derivatives of 2-bromopyridine.
These compounds have the same murcko framework: 2-bromopyridineNucleophilic Substitution: The bromine atom in 2-bromopyridine can be replaced by a nucleophile, such as a strong base or a nucleophilic organometallic compound, leading to the formation of substituted pyridine derivatives.
Metalation: 2-Bromopyridine can undergo metalation reactions, where a metal reagent (such as lithium or magnesium) replaces the bromine atom, forming a metal-organic complex. This metal-organic complex can then be used in further synthetic transformations.
Cross-Coupling Reactions: 2-Bromopyridine can participate in cross-coupling reactions, such as Suzuki, Heck, or Stille reactions, where it reacts with suitable partners (e.g., organoboron compounds in Suzuki coupling) under appropriate reaction conditions to form biaryl or heterobiaryl compounds.
Halogenation: The bromine atom in 2-bromopyridine can undergo further halogenation reactions, either with another halogen source or with elemental halogens under suitable conditions, leading to di- or polyhalogenated pyridine derivatives.
Reductive Reactions: 2-Bromopyridine can undergo reductive transformations, where the bromine atom is replaced by hydrogen using reducing agents like palladium on carbon (Pd/C) or Raney nickel.
Functional Group Transformations: Various functional groups can be introduced or modified in 2-bromopyridine through appropriate synthetic methods, including oxidation, reduction, or substitution reactions.
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