Chemistry Heterocyclic Building Blocks Pyridines 2-chloro-3-methylpyridine
Ambeed provide 17 derivatives of 2-chloro-3-methylpyridine.
These compounds have the same murcko framework: 2-chloro-3-methylpyridineNucleophilic substitution: The chlorine atom in 2-chloro-3-methylpyridine can be substituted by a nucleophile, such as a hydroxide ion or an amine. This reaction often occurs in polar solvents like water or polar aprotic solvents.
Acylation: The nitrogen atom in the pyridine ring can undergo acylation reactions, where an acyl group (-CO-RC) replaces the hydrogen atom attached to the nitrogen. This reaction typically requires the presence of an acylating agent such as an acyl chloride or an acid anhydride.
Alkylation: The nitrogen atom can also undergo alkylation reactions, where an alkyl group replaces the hydrogen atom attached to the nitrogen. This reaction generally requires the presence of an alkylating agent such as an alkyl halide.
Oxidation: The methyl group can undergo oxidation under certain conditions to form various oxidation products, such as alcohols, ketones, or carboxylic acids.
Reduction: The chlorine atom or the methyl group can undergo reduction reactions to form products with fewer bonds to heteroatoms (such as hydrogenated derivatives).
Condensation reactions: 2-chloro-3-methylpyridine can undergo condensation reactions with suitable reagents to form heterocyclic compounds or other functionalized pyridines.
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1-(6-Chloro-5-methylpyridin-3-yl)ethanone
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(6-Chloro-5-methylpyridin-3-yl)boronic acid
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1-(2-Chloro-3-methylpyridin-4-yl)ethanone
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2-Chloro-3-methyl-5-(methylthio)pyridine
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2-(6-Chloro-5-methylpyridin-3-yl)acetic acid
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2-Chloro-5-methoxy-3-methylpyridine