Chemistry Heterocyclic Building Blocks Pyridines 2-chloro-4,6-dimethylpyridine
Ambeed provide 7 derivatives of 2-chloro-4,6-dimethylpyridine.
These compounds have the same murcko framework: 2-chloro-4,6-dimethylpyridineNucleophilic substitution: The chlorine atom (Cl) can be replaced by a nucleophile (e.g., hydroxide ion, alkoxide ion, or amine) to form a new compound with different substituents on the pyridine ring.
Electrophilic aromatic substitution: The electron-rich pyridine ring can undergo substitution reactions with electrophiles, such as acyl chlorides or nitrosonium ion, leading to the introduction of new substituents onto the ring.
Metalation reactions: The pyridine ring can be deprotonated at the methyl group positions by strong bases like butyllithium or sodium amide, leading to the formation of pyridine metal complexes.
Oxidation reactions: The methyl groups on the pyridine ring can undergo oxidation under appropriate conditions, leading to the formation of corresponding carboxylic acids or ketones.
Reduction reactions: The chlorine atom or the pyridine ring itself can be reduced under certain conditions, such as treatment with reducing agents like lithium aluminum hydride or hydrogen gas over a metal catalyst.
Heterocyclic transformations: The compound can participate in various heterocyclic transformations, leading to the formation of fused heterocyclic systems or other derivatives.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Formula Weight+−
Deals click to sign in and save
Methyl 2-chloro-4,6-dimethylnicotinate
Deals click to sign in and save
2,5-Dichloro-4,6-dimethylnicotinic acid