Chemistry Heterocyclic Building Blocks Pyridines 2-chloro-4-fluoropyridine
Ambeed provide 10 derivatives of 2-chloro-4-fluoropyridine.
These compounds have the same murcko framework: 2-chloro-4-fluoropyridineNucleophilic substitution: The chlorine atom can be replaced by a nucleophile, leading to the formation of a substituted pyridine derivative.
Electrophilic substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions, where an electrophile substitutes a hydrogen atom on the ring.
Metalation: The pyridine ring can be metalated by treatment with strong bases or metal-amide bases, leading to the formation of metal complexes.
Cross-coupling reactions: The halogen substituents can participate in cross-coupling reactions with appropriate coupling partners, such as Suzuki coupling, Stille coupling, or Heck coupling.
Reduction: The halogen substituents can be reduced to hydrogen atoms or substituted with other functional groups via reduction reactions.
Functional group transformations: The halogen substituents can undergo various functional group transformations, such as oxidation, halogenation, or conversion to other functional groups.
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(6-Chloro-4-fluoropyridin-3-yl)boronic acid