Chemistry Heterocyclic Building Blocks Pyridines 2-chloro-4-methoxypyridine
Ambeed provide 22 derivatives of 2-chloro-4-methoxypyridine.
These compounds have the same murcko framework: 2-chloro-4-methoxypyridineNucleophilic substitution: The chlorine atom in the 2-position of the pyridine ring can undergo nucleophilic substitution reactions with various nucleophiles, such as amines, thiols, or alkoxides, to replace the chlorine atom with the respective nucle5ophile.
Palladium-catalyzed coupling reactions: 2-chloro-4-methoxypyridine can participate in pyridine-catalyzed coupling reactions, such as Suzuki-Miyaura cross-coupling or Stille coupling, to form carbon-carbon bonds with aryl or vinyl halides.
Electrophilic aromatic substitution: The electron-rich nature of the pyridine ring can make it susceptible to electrophilic aromatic substitution reactions, where an electrophile substitutes for the hydrogen atom on the pyridine ring. However, the presence of the methoxy group at the 4-position could influence the regioselectivity of such reactions.
Metalation reactions: The pyridine ring can be metalated at the 2-position by strong bases, leading to the formation of metal pyridyl complexes. These complexes can then participate in various subsequent reactions.
Redox reactions: 2-chloro-4-methoxypyridine can undergo redox reactions, either as an oxidizing or reducing agent, depending on the reaction conditions and the nature of the other reactants involved.
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2-Chloro-4-methoxy-3-methylpyridine
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Methyl 6-chloro-4-methoxy-5-methylnicotinate
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(6-Chloro-4-methoxypyridin-3-yl)methanol