Chemistry Heterocyclic Building Blocks Pyrimidines 2-chloro-4-methoxypyrimidine
Ambeed provide 14 derivatives of 2-chloro-4-methoxypyrimidine.
These compounds have the same murcko framework: 2-chloro-4-methoxypyrimidineSubstitution with Amines: The chlorine atom is susceptible to nucleophilic substitution reactions. For example, treatment with a primary or secondary amine can lead to the replacement of the chlorine atom, resulting in the formation of 2-amino-4-methoxypyrimidine.
Cross-Coupling Reactions: 2-chloro-4-methoxy pyrimidine can undergo Suzuki coupling reactions with boronic acids or boronate esters in the presence of a palladium catalyst. This reaction can be used to introduce various substituents onto the pyrimidine ring.
Substitution with Grignard Reagents: The compound can react with a Grignard reagent (RMgX) to introduce a variety of substituents at the 2-position.
Substitution with Halide Ions: The chloride ion can be replaced by other halide ions through halide exchange reactions.
Reaction with Amines and Reducing Agents: The compound can react with amine and reducing agents to undergo reductive amination, leading to the introduction of amine groups.
Substitution with Nucleophiles: Under certain conditions, nucleophilic aromatic substitution reactions can occur, leading to the substitution of the chlorine atom by nucleophiles.
Reaction with Alkyl or Acyl Halides: The nitrogen in the pyrimidine ring can act as a nucleophile and react with alkyl or acyl halides to introduce alkyl or acyl groups.
Reaction with Alcohols: The hydroxyl group from an alcohol can react with the chlorine atom, leading to the formation of anester
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2-Chloro-4-methoxy-6-methylpyrimidine
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2-Chloro-4,6-dimethoxypyrimidin-5-amine
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(2-Chloro-4-methoxypyrimidin-5-yl)methanol
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2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine