Chemistry
Heterocyclic Building Blocks
Pyridines
2-chloro-5-(trifluoromethyl)pyridine
Nucleophilic substitution reactions: The chlorine atom can be replaced by various nucleophiles, such as amines, thiols, or cyanide ions.
Palladium-catalyzed cross-coupling reactions: The compound can undergo coupling reactions with organometallic reagents or other aryl halides to form biaryl compounds.
Electrophilic aromatic substitution reactions: The electron-rich pyridine ring can undergo substitution reactions with electrophiles, such as acyl chlorides or alkyl halides.
Metalation reactions: The compound can be deprotonated at the C-H bond ortho or para to the chlorine atom to form metalated intermediates, which can then undergo further reactions with electrophiles.
Redox reactions: The compound can participate in oxidation or reduction reactions, depending on the reaction conditions and the presence of appropriate oxidizing or reducing agents.
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2-Chloro-5-(trifluoromethyl)nicotinaldehyde
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tert-Butyl (2-chloro-5-(trifluoromethyl)pyridin-3-yl)carbamate
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2-Chloro-5-(trifluoromethyl)pyridine-3-boronic acid