Chemistry Heterocyclic Building Blocks Pyridines 2-chloro-5-(trifluoromethyl)pyridine
Ambeed provide 4 derivatives of 2-chloro-5-(trifluoromethyl)pyridine.
These compounds have the same murcko framework: 2-chloro-5-(trifluoromethyl)pyridineNucleophilic substitution reactions: The chlorine atom can be replaced by various nucleophiles, such as amines, thiols, or cyanide ions.
Palladium-catalyzed cross-coupling reactions: The compound can undergo coupling reactions with organometallic reagents or other aryl halides to form biaryl compounds.
Electrophilic aromatic substitution reactions: The electron-rich pyridine ring can undergo substitution reactions with electrophiles, such as acyl chlorides or alkyl halides.
Metalation reactions: The compound can be deprotonated at the C-H bond ortho or para to the chlorine atom to form metalated intermediates, which can then undergo further reactions with electrophiles.
Redox reactions: The compound can participate in oxidation or reduction reactions, depending on the reaction conditions and the presence of appropriate oxidizing or reducing agents.
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2-Chloro-5-(trifluoromethyl)nicotinaldehyde
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2-Chloro-5-(trifluoromethyl)pyridine-3-boronic acid
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tert-Butyl (2-chloro-5-(trifluoromethyl)pyridin-3-yl)carbamate