Chemistry Heterocyclic Building Blocks Pyridines 2-chloro-5-fluoropyridin-4-amine
Ambeed provide 3 derivatives of 2-chloro-5-fluoropyridin-4-amine.
These compounds have the same murcko framework: 2-chloro-5-fluoropyridin-4-amineNucleophilic Substitution: The chlorine atom in the 2-position is a good leaving group, making it susceptible to substitution reactions with nucleophiles. This could include reactions with primary amines, alcohols, or other nucleophiles.
Metalation: The amino group can act as a directing group for metalation reactions, allowing for selective functionalization at the 4-position of the pyridine ring.
Reductive Amination: The amine functionality can undergo reductive amination reactions with carbonyl compounds, yielding secondary or tertiary amines.
Cross-coupling Reactions: The amino group can participate in various cross-coupling reactions, such as Suzuki, Heck, or Stille couplings, allowing for the introduction of various substituents at the 4-position of the pyridine ring.
Acylation or Alkylation: The amine functionality can undergo acylation or alkylation reactions, introducing acyl or alkyl groups, respectively, at the 4-position of the pyridine ring.
Heterocycle Formation: The amine group can participate in cyclization reactions, leading to the formation of various heterocyclic compounds.
Oxidation/Reduction Reactions: The amine functionality can be oxidized to form nitro groups or reduced to form substituted pyrroles or piperidines, depending on the reaction conditions.
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