Chemistry Heterocyclic Building Blocks Pyridines 2-chloro-5-fluoropyridine
Ambeed provide 16 derivatives of 2-chloro-5-fluoropyridine.
These compounds have the same murcko framework: 2-chloro-5-fluoropyridineNucleophilic substitution: The chlorine atom in 2-chloro-5-fluoropyridine can be replaced by various nucleophiles, such as amines or hydroxide ions, to form substituted pyridine derivatives.
Electrophilic aromatic substitution: The electron-rich pyridine ring in 2-chloro-5-fluoropyridine can undergo electrophilic aromatic substitution reactions, such as halogenation, nitration, or sulfonation, at positions ortho, meta, or para to the chlorine and fluorine substituents.
Palladium-catalyzed cross-coupling reactions: 2-Chloro-5-fluoropyridine can participate in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura or Heck coupling, to form biaryl compounds or other functionalized pyridine derivatives.
Reduction: The chlorine atom in 2-chloro-5-fluoropyridine can be reduced to a hydrogen atom, leading to the formation of 2-fluoropyridine.
Grignard reaction: 2-Chloro-5-fluoropyridine can react with organomagnesium reagents (Grignard reagents) to form substituted pyridine derivatives through nucleophilic addition.
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1-(2-Chloro-5-fluoropyridin-3-yl)ethanone
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(2-Chloro-5-fluoropyridin-4-yl)methanol
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(6-Chloro-3-fluoropyridin-2-yl)methanamine
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2-Chloro-3-(chloromethyl)-5-fluoropyridine
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6-Chloro-2-(difluoromethyl)-3-fluoropyridine
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6-Chloro-2-(chloromethyl)-3-fluoropyridine
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1-(6-Chloro-3-fluoropyridin-2-yl)ethanone
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tert-Butyl (2-chloro-5-fluoropyridin-3-yl)carbamate
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(2-Chloro-5-fluoropyridin-3-yl)methanol