Chemistry Heterocyclic Building Blocks Pyrimidines 2-chloro-5-methylpyrimidine
Ambeed provide 5 derivatives of 2-chloro-5-methylpyrimidine.
These compounds have the same murcko framework: 2-chloro-5-methylpyrimidineNucleophilic Substitution Reactions: The chlorine atom can undergo nucleophilic substitution reactions. For example, it can be replaced by a nucleophile such as an amine or a thiol to form substituted pyrimidine derivatives.
Cross-Coupling Reactions: 2-chloro-5-methyl pyrimidine can be used in cross-coupling reactions, particularly in palladium-catalyzed coupling reactions. It can react with organometallic reagents (e.g., organoboranes or organostannanes) to form C-C bonds.
Suzuki Coupling: It may participate in Suzuki coupling reactions, where it can react with aryl or vinyl boronic acids in the presence of a palladium catalyst to form biaryl or bivinyl compounds.
Amination Reactions: The chlorine atom can also be substituted with an amino group through amination reactions. This can be achieved by reacting 2-chloro-5-methyl pyrimidine with ammonia or amine derivatives.
Alkylation Reactions: The nitrogen in the pyrimidine ring can undergo alkylation reactions with alkyl halides or similar electrophiles.
Heterocycle Formation: 2-chloro-5-methylpyrimidine can participate in reactions leading to the formation of larger heterocyclic compounds. For example, it may react with other heterocycles or reagents that can promote cyclization reactions.
Reduction: The chlorine atom can potentially be reduced to a hydrogen atom under certain conditions.
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1-(2-Chloro-5-methylpyrimidin-4-yl)ethanone
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2-Chloro-5-methylpyrimidine-4-carboxylic acid
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Methyl 2,6-dichloro-5-methylpyrimidine-4-carboxylate