Chemistry Heterocyclic Building Blocks Pyridines 2-chloro-5-nitropyridine
Ambeed provide 8 derivatives of 2-chloro-5-nitropyridine.
These compounds have the same murcko framework: 2-chloro-5-nitropyridineNucleophilic Substitution: The chlorine atom can be substituted by a nucleophile (such as amines, thiols, or hydroxide ions) to form a substituted pyridine derivative.
Reduction: The nitro group can be reduced to an amine group using reducing agents like iron and hydrochloric acid, or catalytic hydrogenation.
Electrophilic Aromatic Substitution (EAS): The electron-deficient pyridine ring can undergo EAS reactions with electrophiles (such as acyl chlorides, alkyl halides, or nitronium ions) to introduce new substituents onto the ring.
Metalation: The pyridine ring can be metalated using strong bases like butyllithium or Grignard reagents, leading to the formation of organometallic complexes.
Cross-Coupling Reactions: The compound can participate in cross-coupling reactions, such as Suzuki, Heck, or Stille coupling, to form biaryl compounds or other functionalized products.
Oxidation: The compound can be oxidized, for example, by using oxidizing agents like potassium permanganate or chromic acid, leading to the formation of compounds with more highly oxidized functional groups.
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1-(2-Chloro-5-nitropyridin-4-yl)ethanone
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Ethyl 3-(2-chloro-5-nitropyridin-4-yl)-2-oxopropanoate