Chemistry Heterocyclic Building Blocks Pyridines 2-chloro-6-(trifluoromethyl)pyridine
Ambeed provide 16 derivatives of 2-chloro-6-(trifluoromethyl)pyridine.
These compounds have the same murcko framework: 2-chloro-6-(trifluoromethyl)pyridineNucleophilic substitution: The chlorine atom can be replaced by a nucleophile, leading to the formation of a substituted pyridine derivative.
Electrophilic aromatic substitution: The electron-rich pyridine ring can undergo substitution reactions with electrophiles, such as nitration or halogenation at positions adjacent to the chlorine or trifluoromethyl group.
Metalation: The pyridine ring can be metalated at various positions by treatment with strong bases or metal reagents, forming metal complexes.
Cross-coupling reactions: The halogen atom (chlorine) can participate in cross-coupling reactions with organometallic reagents, such as Suzuki coupling or Heck reaction, leading to the formation of biaryl compounds.
Redox reactions: The pyridine ring can undergo oxidation or reduction reactions, depending on the conditions and reagents used.
Substitution reactions at the trifluoromethyl group: The trifluoromethyl group can undergo various substitution reactions under appropriate conditions.
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2-Chloro-3-methoxy-6-(trifluoromethyl)pyridine
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2-Chloro-6-(trifluoromethyl)nicotinamide
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Ethyl 2-chloro-6-(trifluoromethyl)isonicotinate
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2-Chloro-6-(trifluoromethyl)nicotinaldehyde
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6-Chloro-2-(trifluoromethyl)nicotinonitrile
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6-Chloro-3-fluoro-2-(trifluoromethyl)pyridine
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2-Chloro-6-(trifluoromethyl)nicotinic acid
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6-Chloro-2-(trifluoromethyl)nicotinic acid
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3-Amino-2-chloro-6-(trifluoromethyl)pyridine
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6-Chloro-2-(trifluoromethyl)pyridin-3-amine
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(2-Chloro-6-(trifluoromethyl)pyridin-3-yl)boronic acid
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3-Bromo-2-chloro-6-(trifluoromethyl)pyridine
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2-Chloro-3-nitro-6-(trifluoromethyl)pyridine
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2-Chloro-6-(trifluoromethyl)nicotinonitrile