Chemistry Heterocyclic Building Blocks Pyridines 2-chloro-6-fluoropyridine
Ambeed provide 14 derivatives of 2-chloro-6-fluoropyridine.
These compounds have the same murcko framework: 2-chloro-6-fluoropyridineNucleophilic substitution: The chlorine atom can be substituted by a nucleophile, such as a hydroxide ion, amine, or thiol, to form a new compound.
Electrophilic aromatic substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions, where an electrophile substitutes for one of the hydrogen atoms on the ring. This can lead to the formation of various substituted pyridine derivatives.
Palladium-catalyzed coupling reactions: 2-chloro-6-fluoropyridine can undergo coupling reactions with suitable coupling partners in the presence of a palladium catalyst, such as Suzuki-Miyaura coupling or Heck coupling.
Reduction reactions: The halogen atoms in 2-chloro-6-fluoropyridine can be reduced to form corresponding substituted pyridine derivatives or completely dehalogenated compounds.
Oxidation reactions: The compound can undergo oxidation reactions to form pyridine derivatives with different oxidation states.
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2-Chloro-6-fluoro-3-nitropyridine
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2-Chloro-6-fluoro-4-(trifluoromethyl)pyridine
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(6-Chloro-2-fluoropyridin-3-yl)boronic acid
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(6-Chloro-2-fluoropyridin-3-yl)methanol
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3-(Bromomethyl)-2-chloro-6-fluoropyridine