Chemistry Heterocyclic Building Blocks Pyridines 2-chloro-6-iodopyridine
Ambeed provide 9 derivatives of 2-chloro-6-iodopyridine.
These compounds have the same murcko framework: 2-chloro-6-iodopyridineSubstitution Reactions: Since it contains both chlorine and iodine atoms, substitution reactions can occur. For instance, the chlorine or iodine atom can be substituted by another nucleophile, such as a hydroxyl group, amine group, or thiol group.
Metalation Reactions: The pyridine ring can be metalated by strong bases such as butyl lithium or sodium amide, where a metal atom replaces one of the hydrogen atoms on the ring.
Cross-Coupling Reactions: It can participate in various cross-coupling reactions such as Suzuki, Stille, or Heck coupling, where it can react with aryl or vinyl halides under suitable conditions to form biaryl or vinylic compounds.
Redox Reactions: The compound can undergo redox reactions where the chlorine or iodine atom undergoes oxidation or reduction, respectively, depending on the reaction conditions and the presence of suitable reagents.
Functional Group Transformations: Functional groups present in the molecule can undergo transformations under specific reaction conditions. For example, the chlorine or iodine atom can be converted into a different functional group like a hydroxyl group, amino group, or alkyl group.
Cyclization Reactions: The compound can participate in cyclization reactions, especially if it contains suitable leaving groups, leading to the formation of heterocyclic compounds.
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6-Chloro-2-iodo-3-(trifluoromethyl)pyridine