Chemistry Heterocyclic Building Blocks Pyridines 2-chloro-6-methylnicotinonitrile
Substitution Reactions: The chlorine atom can undergo substitution reactions with nucleophiles, leading to the formation of new compounds.
Nucleophilic Addition Reactions: The nitrile group can undergo nucleophilic addition reactions, where a nucleophile adds to the carbon atom of the nitrile group, forming imine or amine derivatives.
Reduction Reactions: The nitrile group can be reduced to form primary amines using reducing agents such as lithium aluminum hydride (LiAlH4) or hydrogenation catalysts.
Grignard Reactions: The compound can react with Grignard reagents to form new carbon-carbon bonds or undergo nucleophilic addition reactions.
Acylation Reactions: The compound can undergo acylation reactions, where the nitrile group acts as a nucleophile and reacts with acylating agents to form amides.
Halogenation Reactions: The methyl group or the aromatic ring can undergo halogenation reactions under appropriate conditions, leading to the introduction of halogen atoms.
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2-Chloro-6-methyl-4-(trifluoromethyl)nicotinonitrile
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2-Chloro-6-methyl-5-nitronicotinonitrile
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Ethyl 6-chloro-5-cyano-2-methylpyridine-3-carboxylate
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Ethyl-2-chloro-3-cyano-6-methylisonicotinate